RNA Viruses: Host Gene Responses to Infections

RNA Viruses: Host Gene Responses to Infections

By Decheng Yang
- Publisher: World Scientific Publishing Company

- Number Of Pages: 691

- Publication Date: 2009-05-30

- ISBN-10 / ASIN: 981283379X

- ISBN-13 / EAN: 9789812833792
Product Description:

This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; host innate and adapted immune responses to viral replication in target organs; virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and, the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection.Organized into 29 highly accessible and well-illustrated chapters, this volume explores state-of-the-art knowledge of the molecular mechanisms of RNA virus infection and host-virus interactions. This comprehensive compilation of the altered gene expression profiles and signal transduction pathways in host cells in response to the majority of human/animal RNA viruses opens new directions for basic and clinical research on viral pathogenesis, and also provides valuable biomarkers for researchers to select gene targets in the development of diagnostic tests and antiviral therapeutics for a number of infectious diseases.

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The International Response to Highly Pathogenic Avian Influenza Science, Policy and Politics

The International Response to Highly Pathogenic Avian Influenza Science, Policy and Politics
Publisher: Institute for Development Studies (IDS)

Published: October 7, 2008

Pages: 103ISBN 10: 1858645441

ISBN 13: 9781858645445
On June 11th 2008 another outbreak of highly pathogenic avian influenza (H5N1) was reported inong Kong – the site of the first reported human deaths from this virus in 1997. Media reports portrayed the possibility of a major catastrophe. Anxious citizens stopped eating chicken. With China hosting the Olympics in a matter of weeks, concerns were raised in the highest circles about the consequences of an outbreak – for world profile and for business. Politicians wanted firm action. On June 20th, officials proposed a package of US$128 million to put the small-scale poultry sector and wet markets out of business. Traders have rejected the proposal, and many consumers argue that the alternative frozen supermarket chickens are not what they want. Others argue that attempts at regulating imports and banning wet markets are futile. Informal, unregulated trade abounds, and with South China being a known, if poorly reported, hot spot of avian influenza virus circulation, the chances of keeping Hong Kong free of the disease are very small indeed. Yet, sceptics argue that the proposed measures are more about political grandstanding and public relations than sensible, science-based control policies. They argue that the net consequences for farmers’, traders’ and poorer consumers’ livelihoods will be negative, with only the ell-connected large suppliers and supermarkets benefiting. But, given the fears around viral mutation into a form capable of efficient human-to-human transmission, others conclude that precaution, even if drastic, is the most appropriate route1 ...

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